There aren't any specific instructions for left-handers in the books, but we have had many left-handers enjoy our books!
A couple tips for lefties:
We typically advise lefties to remove the coil spine of the book so their hand can lay flat on the table.
We suggest using tracing paper to cover your work as you go. This prevents smudging.
The great thing about Lisa's method of lettering is that she makes it really easy to connect everything so you can lift your hand between letters. This was a game changer, most letterers do everything in one continuous word without lifting their pen, but if you're just getting started that's REALLY hard to do. Instead, you'll learn how to finish each letter so you can easily start the next, which is also a great method for lefties.